Mescaline → 2-Formyl-3,4,5-trimethoxy-phenylethylamine

HRID 1155502

反応式

HRID 1155502 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:13][CH2:14][NH2:15])[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[C:16](OC(=O)C)(=[O:18])C>C(O)=O>[CH:16]([CH:13]([C:5]1[CH:6]=[C:7]([O:11][CH3:12])[C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=1)[CH2:14][NH2:15])=[O:18]

参加物

4

反応物 2

HCID 4076MescalineHCID 7918Acetic Anhydride

生成物 1

HCID 867381162-Formyl-3,4,5-trimethoxy-phenylethylamine

試薬・触媒・溶媒 1

HCID 284Formic Acid溶媒

実験手順

1.422 kg of 3,4,5-trimethoxy-phenylethylamine is slowly added to a mixture of 2.185 kg of 98% formic acid and 1.728 kg of acetic anhydride, while maintaining the temperature at about 50°. The reaction bath is maintained at this temperature for about 3 hours and the formic acid and acetic acid mixture and the excess anhydride is distilled. The formylated derivative thus obtained (1.734 kg) is used unpurified.

後処理

  1. temperaturewhile maintaining the temperature at about 50°
  2. temperatureThe reaction bath is maintained at this temperature for about 3 hours
  3. distillationthe formic acid and acetic acid mixture and the excess anhydride is distilled
  4. customThe formylated derivative thus obtained (1.734 kg)

出典と根拠

ORDレコード
ord-19c0d8cc26114b74b636f14f770ebde7
出典データセット
uspto-grants-1981_11
特許番号
US04302458

関連ノート

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