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Diisopropylamine → N-[3-(4-methylpiperazin-1-yl)propyl]-4-nitro-1-aminobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylamine | HCID 7912 | — |
| 反応物 | p-Fluoronitrobenzene | HCID 9590 | — |
| 反応物 | 1-(3-Aminopropyl)-4-methylpiperazine | HCID 78328 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | N-[3-(4-methylpiperazin-1-yl)propyl]-4-nitro-1-aminobenzene | HCID 21975010 | — |
反応手順
A mixture of 4.44 mL of p-fluoronitrobenzene, 6 gms. 3-(4-methyl-piperazin-1-yl)-propylamine and 6.65 mL N,N-diisopropylamine in 19 mL dioxane is heated at 105° C. for 2 days. The reaction mixture is cooled to room temperature, evaporated to dryness, and recrystallized from hot isopropanol yielding [3-(4-methyl-piperazin-1-yl)-propyl]-(4-nitro-phenyl)-amine in the amount of 0.1385 gms.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07098236B2 |
| 出典データセット | uspto-grants-2006_08 |
| ORD ID | ord-bd5c83c4a79a42c4a343217e1748191c |
| 出典メモ | uspto-grants-2006_08 |