Methanol → 3-[2-(2-Cyano-3-methylguanidino)-ethylsulphinylmethyl]-5-guanidino-1,2,4-thiadiazole

HRID 1155778ノート

反応式

HRID 1155778 の反応式
[C:1]([N:3]=[C:4]([NH:19][CH3:20])[NH:5][CH2:6][CH2:7][S:8][CH2:9][C:10]1[N:14]=[C:13]([NH:15][C:16]([NH2:18])=[NH:17])[S:12][N:11]=1)#[N:2].I([O-])(=O)(=O)=[O:22].[Na+].CO>O>[C:1]([N:3]=[C:4]([NH:19][CH3:20])[NH:5][CH2:6][CH2:7][S:8]([CH2:9][C:10]1[N:14]=[C:13]([NH:15][C:16]([NH2:18])=[NH:17])[S:12][N:11]=1)=[O:22])#[N:2]

参加物

5

反応物 3

HCID 887MethanolHCID 23667635Sodium periodateHCID 178485071HCID 178485071、化合物

生成物 1

HCID 1784850733-[2-(2-Cyano-3-methylguanidino)-ethylsulphinylmethyl]-5-guanidino-1,2,4-thiadiazole

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 3-[2-(2-cyano-3-methylguanidino)-ethylthiomethyl]-5-guanidino-1,2,4-thiadiazole (0.626 g.), sodium metaperiodate (0.428 g.), methanol (20 ml.) and water (70 ml.) was stirred overnight at room temperature. The reaction mixture was evaporated to dryness and the residue extracted with absolute ethanol (120 ml.). The extract was filtered and evaporated to dryness. The residue was crystallised from methanol (with charcoal treatment) to give 3-[2-(2-cyano-3-methylguanidino)-ethylsulphinylmethyl]-5-guanidino-1,2,4-thiadiazole as a white powder, m.p. 185°-186°.

後処理

  1. customThe reaction mixture was evaporated to dryness
  2. extractionthe residue extracted with absolute ethanol (120 ml.)
  3. filtrationThe extract was filtered
  4. customevaporated to dryness
  5. customThe residue was crystallised from methanol (with charcoal treatment)

出典と根拠

ORDレコード
ord-9cbde29e005c45d49513d51444c12fed
出典データセット
uspto-grants-1982_06
特許番号
US04332949

反応ノート

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