Chlorosuccinimide → 2-(2-Methoxy-5-bromophenyl)-2-methyl-1-chloropropyl methyl sulphide

HRID 1155951

反応式

HRID 1155951 の反応式
[Cl:1]N1C(=O)CCC1=O.[CH3:9][S:10][CH2:11][C:12]([C:15]1[CH:20]=[C:19]([Br:21])[CH:18]=[CH:17][C:16]=1[O:22][CH3:23])([CH3:14])[CH3:13]>C(Cl)(Cl)(Cl)Cl>[CH3:9][S:10][CH:11]([Cl:1])[C:12]([C:15]1[CH:20]=[C:19]([Br:21])[CH:18]=[CH:17][C:16]=1[O:22][CH3:23])([CH3:14])[CH3:13]

参加物

4

反応物 2

HCID 31398ChlorosuccinimideHCID 205362252-(2-Methoxy-5-bromophenyl)-2-methyl-1-propyl methyl sulphide

生成物 1

HCID 205362412-(2-Methoxy-5-bromophenyl)-2-methyl-1-chloropropyl methyl sulphide収率 99%

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

反応条件

温度
40 °C

実験手順

N-Chlorosuccinimide (37.4 g, 0.28 mole) was added portionwise to 2-(2-methoxy-5-bromophenyl)-2-methyl-1-propyl methyl sulphide (79.3 g, 0.275 mole) in carbon tetrachloride (250 ml) at room temperature. An exothermic reaction ensued, the temperature being allowed to rise to 40° C. before control with an external cooling bath was applied. After addition, the reaction mixture was heated at about 40° C. for 4 hours, then cooled, filtered and run down yielding 88 g crude title product (99%).

後処理

  1. customAn exothermic reaction
  2. customto rise to 40° C. before control with an external cooling bath
  3. additionAfter addition
  4. temperaturecooled
  5. filtrationfiltered

出典と根拠

ORDレコード
ord-a2d260978173422394f8b311d9065c30
出典データセット
uspto-grants-1982_06
特許番号
US04333759

関連ノート

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