Dimethylformamide → 5-Cyano-2,3-dihydro-3,3-dimethylbenzofuran

HRID 1155956ノート

反応式

HRID 1155956 の反応式
Br[C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH2:8][C:7]([CH3:11])([CH3:10])[C:6]=2[CH:12]=1.[CH3:13][N:14](C)C=O>>[C:13]([C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH2:8][C:7]([CH3:11])([CH3:10])[C:6]=2[CH:12]=1)#[N:14]

参加物

3

反応物 2

HCID 6228DimethylformamideHCID 53235955-Bromo-3,3-dimethyl-2,3-dihydro-1-benzofuran

生成物 1

HCID 205361905-Cyano-2,3-dihydro-3,3-dimethylbenzofuran

実験手順

5-Bromo-2,3-dihydro-3,3-dimethylbenzofuran (15 g, 0.066 mole) was heated under reflux with cuprous cyanide (7.2 g, 0.08 mole) in dimethyl formamide (15 ml) as in Example 2. Work up yielded, after recrystallisation from petroleum ether (bp 60°-80° C.) with charcoaling, 5.7 g of product, mp 72°-75° C.

後処理

  1. customWork up yielded
  2. customafter recrystallisation from petroleum ether (bp 60°-80° C.) with charcoaling, 5.7 g of product, mp 72°-75° C.

出典と根拠

ORDレコード
ord-c82f93d08ea64243962a22e32b72a3d9
出典データセット
uspto-grants-1982_06
特許番号
US04333759

反応ノート

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