Potassium Hydroxide → 9-Chlorodibenzothiophene-3-acetic acid

HRID 1156169ノート

反応式

HRID 1156169 の反応式
[OH-].[K+].C([O:5][C:6](=[O:22])[CH2:7][C:8]1[CH:9]=[CH:10][C:11]2[C:15]3[C:16]([Cl:20])=[CH:17][CH:18]=[CH:19][C:14]=3[S:13][C:12]=2[CH:21]=1)C>C(O)C>[Cl:20][C:16]1[C:15]2[C:11]3[CH:10]=[CH:9][C:8]([CH2:7][C:6]([OH:22])=[O:5])=[CH:21][C:12]=3[S:13][C:14]=2[CH:19]=[CH:18][CH:17]=1

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 130651209-Chlorodibenzothiophene-3-acetic acid ethyl ester

生成物 1

HCID 130651199-Chlorodibenzothiophene-3-acetic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a 100 ml. flask, fitted with a condenser and containing a solution of 0.28 g. of potassium hydroxide in 50 ml. of ethanol was added 1.1 g. of 9-chlorodibenzothiophene-3-acetic acid ethyl ester. After the solution was refluxed for four hours, the solvent was removed in vacuo on the steam bath, the residue was dissolved in 50 ml. of water, and the aqueous solution was acidified with dilute hydrochloric acid. The product was filtered, washed with 20 ml. of water, and dried at 60° in a vacuum over for 12 hours. The yield of 9-chlorodibenzothiophene-3-acetic acid, after crystallization from methanol, was 0.8 g. (m.p. 203°-206°).

後処理

  1. customflask, fitted with a condenser
  2. additioncontaining a solution of 0.28 g
  3. temperatureAfter the solution was refluxed for four hours
  4. customthe solvent was removed in vacuo on the steam bath
  5. dissolutionthe residue was dissolved in 50 ml
  6. filtrationThe product was filtered
  7. washwashed with 20 ml
  8. dry with materialof water, and dried at 60° in a vacuum over for 12 hours
  9. customThe yield of 9-chlorodibenzothiophene-3-acetic acid, after crystallization from methanol

出典と根拠

ORDレコード
ord-0c815fd9e5be4a63b21f7d665182c4fe
出典データセット
uspto-grants-1982_06
特許番号
US04334078

反応ノート

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