HCID 20535629、化合物 → CHROMONE2CARBOXYLICACID52HYDROXYPROPOXY8PROPYL

HRID 1156225ノート

反応式

HRID 1156225 の反応式
O1CCCCC1[O:7][CH:8]([CH3:28])[CH2:9][O:10][C:11]1[C:16]2[C:17](=[O:24])[CH:18]=[C:19]([C:21]([OH:23])=[O:22])[O:20][C:15]=2[C:14]([CH2:25][CH2:26][CH3:27])=[CH:13][CH:12]=1>C(O)C.O.Cl>[OH:7][CH:8]([CH3:28])[CH2:9][O:10][C:11]1[C:16]2[C:17](=[O:24])[CH:18]=[C:19]([C:21]([OH:23])=[O:22])[O:20][C:15]=2[C:14]([CH2:25][CH2:26][CH3:27])=[CH:13][CH:12]=1

参加物

5

反応物 1

HCID 20535629HCID 20535629、化合物

生成物 1

HCID 121899CHROMONE2CARBOXYLICACID52HYDROXYPROPOXY8PROPYL

試薬・触媒・溶媒 3

HCID 313Hydrochloric Acid触媒HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

A suspension of 5-[2-(tetrahydropyran-2-yloxy)propoxy]-4-oxo-8-propyl-4H-1-benzopyran-2-carboxylic acid (0.12 g) in ethanol (3 ml), water (2 ml) and concentrated hydrochloric acid (1 drop) was stirred for 15 minutes at ambient temperature. The mixture was then extracted with chloroform (3×20 ml) and the chloroform extracts bulked, dried and evaporated in vacuo. The residue was crystallised from acetone giving 5-(2-hydroxypropoxy)-4-oxo-8-propyl-4H-1-benzopyran-2-carboxylic acid m.g. 134°-135° C.

後処理

  1. extractionThe mixture was then extracted with chloroform (3×20 ml)
  2. customdried
  3. customevaporated in vacuo
  4. customThe residue was crystallised from acetone

出典と根拠

ORDレコード
ord-b0ea262d5a494c7eae27cdfd0e2e25cd
出典データセット
uspto-grants-1982_06
特許番号
US04335048

反応ノート

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