2-Bromoethanol → 2-[4-(2-hydroxyethoxy)phenyl]acetonitrile

HRID 1156269ノート

反応式

HRID 1156269 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]#[N:10])=[CH:4][CH:3]=1.Br[CH2:12][CH2:13][OH:14].C(=O)([O-])[O-].[K+].[K+]>CC(CC)=O>[OH:14][CH2:13][CH2:12][O:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]#[N:10])=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 108982-BromoethanolHCID 11430Potassium Carbonate2 回HCID 265484-Hydroxybenzyl cyanide

生成物 1

HCID 205357162-[4-(2-hydroxyethoxy)phenyl]acetonitrile

試薬・触媒・溶媒 1

HCID 6569Methyl Ethyl Ketone溶媒

実験手順

5 g p-hydroxyphenylacetonitrile were dissolved in 250 ml methylethylketone. 7 g of 2-bromoethanol and 23 g potassium carbonate were added thereto. The mixture was stirred for 48 hours under reflux. At the end of the reaction the potassium carbonate and the produced potassium bromide were filtered. The precipitates were washed with acetone and the acetone wash was added to the reaction mixture. The clear solution was reduced to about 10-15 ml. It was then taken up in ether and shaken with 1/100 N sodium hydroxide.

後処理

  1. temperatureunder reflux
  2. filtrationthe produced potassium bromide were filtered
  3. washThe precipitates were washed with acetone
  4. washthe acetone wash
  5. additionwas added to the reaction mixture
  6. stirringshaken with 1/100 N sodium hydroxide

出典と根拠

ORDレコード
ord-047de5666281495d9b1c7b4f58342c0b
出典データセット
uspto-grants-1982_06
特許番号
US04335119

反応ノート

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