Hexane → 1-(1-Methyl-2-phenoxyethylamino)-3-(3-hydroxyphenoxy)-2-propanol

HRID 1156518ノート

反応式

HRID 1156518 の反応式
[O:1]1[CH2:12][CH:2]1[CH2:3][O:4][C:5]1[CH:6]=[C:7]([OH:11])[CH:8]=[CH:9][CH:10]=1.[CH3:13][CH:14]([NH2:23])[CH2:15][O:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.CCCCCC>CCOCC>[CH3:13][CH:14]([NH:23][CH2:12][CH:2]([OH:1])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([OH:11])[CH:6]=1)[CH2:15][O:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

参加物

5

反応物 3

HCID 8058HexaneHCID 370871-Phenoxy-2-propanamineHCID 205347983-(2,3-Epoxy-1-propoxy)-phenol

生成物 1

HCID 128557371-(1-Methyl-2-phenoxyethylamino)-3-(3-hydroxyphenoxy)-2-propanol収率 38%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

A mixture of 1.66 g. (10 mmole) of 3-(2,3-epoxy-1-propoxy)-phenol and 4.5 g. (30 mmole) of 1-methyl-2-phenoxyethylamine was heated at 80° C. overnight. The mixture was taken up in ether, and hexane was added to precipitate the product. Recrystallization from ethyl acetate gave 1-(1-methyl-2-phenoxyethylamino)-3-(3-hydroxyphenoxy)-2-propanol (38%); mp 124°-127° C.

後処理

  1. additionA mixture of 1.66 g
  2. customto precipitate the product
  3. customRecrystallization from ethyl acetate

出典と根拠

ORDレコード
ord-661f65f7a00540aa92488398a9300aed
出典データセット
uspto-grants-1982_06
特許番号
US04336261

反応ノート

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