Glycidol → HCID 12855751、化合物
反応式
[CH3:1][C:2]([NH2:12])([CH3:11])[CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[CH2:13]1[O:15][CH:14]1[CH2:16][OH:17]>CC(O)C>[CH3:11][C:2]([NH:12][CH2:13][CH:14]([OH:15])[CH2:16][OH:17])([CH3:1])[CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1参加物
4
反応条件
- 温度
- 75 °C
実験手順
To 1,1-dimethyl-3-phenylpropylamine (3.6 g., 22 mmole) in 20 ml. 2-propanol at 50° C. in an oil bath was added glycidol (1.7 g., 23 mmole) in 10 ml. 2-propanol dropwise over 5-10 min. The mixture was heated at 75° C. for 2 hours. After evaporation of the solvent, vacuum distillation provided 3.9 g. (75%) of 3-(1,1-dimethyl-3-phenylpropylamino)-1,2-dihydroxypropane (bp 160°-180°/0.5 mm which crystallized upon standing (mp 74°-77° C.).
後処理
- customAfter evaporation of the solvent, vacuum distillation
- customprovided 3.9 g
- custom(75%) of 3-(1,1-dimethyl-3-phenylpropylamino)-1,2-dihydroxypropane (bp 160°-180°/0.5 mm which crystallized
出典と根拠
- ORDレコード
- ord-efee8ac98e8f436082c9ca37ad34aaee
- 出典データセット
- uspto-grants-1982_06
- 特許番号
- US04336261
反応ノート
読み込み中…