化工社化工社 化学情報印刷レポート · 研究参考用
Phosphorus oxychloride → 1-(m-Methoxyphenyl)-2-cyclohexene-1-propionitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | Sodium borohydride | HCID 4311764 | — |
| 反応物 | 1-(m-Methoxyphenyl)-2-cyclohexene-1-acetonitrile | HCID 12838393 | — |
| 反応物 | 1-(m-Methoxyphenyl)-2-hydroxycyclohexane-1-propionitrile | HCID 20460002 | — |
| 反応物 | 1-(m-Methoxyphenyl)-2-oxo-cyclohexane-propionitrile | HCID 20460008 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | 1-(m-Methoxyphenyl)-2-cyclohexene-1-propionitrile | HCID 20460009 | — |
反応手順
By reducing 1-(m-methoxyphenyl)-2-oxo-cyclohexane-propionitrile with sodium borohydride and subsequently dehydrating the resulting 1-(m-methoxyphenyl)-2-hydroxycyclohexane-1-propionitrile with phosphorus oxychloride in pyridine in analogy to the preparation of 1-(m-methoxyphenyl)-2-cyclohexene-1-acetonitrile described in Example 1, there is obtained 1-(m-methoxyphenyl)-2-cyclohexene-1-propionitrile in the form of a pale yellowish oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04336268 |
| 出典データセット | uspto-grants-1982_06 |
| ORD ID | ord-5e318f59c1504313a786d010c71df5a7 |
| 出典メモ | uspto-grants-1982_06 |