関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Trichloroacetyl chloride | HCID 6420 | — |
| 反応物 | N-Methyl-3-(trichloromethyl)-1,2,4-thiadiazol-5-amine | HCID 13150493 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 5-(N-Methyl-Trichloroacetamido)-3-Trichloromethyl-1,2,4-Thiadiazole | HCID 12851602 | 92% |
反応手順
A solution of 5.8 grams (0.02 mole) 5-methylamino-3-trichloromethyl-1,2,4-thiadiazole and 9.0 grams (0.05 mole) trichloroacetyl chloride in 200 milliliters toluene was refluxed at about 110° C. for 20 hours. Upon cooling to -10° C., 2.7 grams pure product precipitated; m.p. 223° C. An additional 6.0 grams product was isolated by removal of the low boiling materials in vacuo. Total yield was 92%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04337081 |
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| 出典データセット | uspto-grants-1982_06 |
|---|
| ORD ID | ord-36de979bf96c461c9ee5e39d26fdcd9c |
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| 出典メモ | uspto-grants-1982_06 |
|---|
