Diphenyl disulfide → 1-(4-Fluorophenyl)-5-methylisoquinoline

反応式

C1(SSC2C=CC=CC=2)C=CC=CC=1.[F:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[C:31]3[C:26](=[C:27]([CH3:32])[CH:28]=[CH:29][CH:30]=3)[CH2:25][CH2:24][N:23]=2)=[CH:18][CH:17]=1>>[F:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[C:31]3[C:26](=[C:27]([CH3:32])[CH:28]=[CH:29][CH:30]=3)[CH:25]=[CH:24][N:23]=2)=[CH:18][CH:17]=1

参加物

反応物 2

HCID 13436Diphenyl disulfide

HCID 128518221-(4-Fluorophenyl)-5-methyl-3,4-dihydroisoquinoline

生成物 1

HCID 128518351-(4-Fluorophenyl)-5-methylisoquinoline

実験手順

Diphenyl disulfide was reacted with 1-(4-fluorophenyl)-5-methyl-3,4-dihydroisoquinoline in the same way as in step (c) of Example 1 to afford 1-(4-fluorophenyl)-5-methylisoquinoline as colorless needles having a melting point of 91° to 92° C.

出典と根拠

ORDレコード: ord-e84c131ded2844009499b2f176ab999e
出典データセット: uspto-grants-1982_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04337256

反応ノート

読み込み中…