N-hydroxymethyl dichloroacetamide → 1-Sec-butyl-5-dichloroacetylaminomethylisoquinoline
反応式
[CH:1]([C:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH:8]=[CH:7][N:6]=1)([CH2:3][CH3:4])[CH3:2].O[CH2:16][NH:17][C:18](=[O:22])[CH:19]([Cl:21])[Cl:20]>>[CH:1]([C:5]1[C:14]2[C:9](=[C:10]([CH2:16][NH:17][C:18](=[O:22])[CH:19]([Cl:21])[Cl:20])[CH:11]=[CH:12][CH:13]=2)[CH:8]=[CH:7][N:6]=1)([CH2:3][CH3:4])[CH3:2]参加物
3
実験手順
1-sec-Butylisoquinoline and N-hydroxymethyl dichloroacetamide were reacted in the same way as in step (b) of Example 18 to afford 1-sec-butyl-5-dichloroacetylaminomethylisoquinoline. The product was reacted successively in the same way as in steps (c), (d), (e) and (f) of Example 18 to obtain 1-sec-butylisoquinoline-5-acetonitrile. The product was treated in the same way as in Example 3 to afford 1-sec-butylisoquinoline-5-acetic acid as an oil.
出典と根拠
- ORDレコード
- ord-cba616a7370140b8911dd513af5006df
- 出典データセット
- uspto-grants-1982_06
- 特許番号
- US04337256
反応ノート
読み込み中…