4-Toluenesulfonyl chloride → 2-Methyl-6-tosyloxymethyl-4,5,6,7-tetrahydrobenzo[d]thiazole

反応式

[C:1]1([CH3:11])[CH:6]=[CH:5][C:4]([S:7](Cl)(=[O:9])=[O:8])=[CH:3][CH:2]=1.[CH3:12][C:13]1[S:14][C:15]2[CH2:21][CH:20]([CH2:22][OH:23])[CH2:19][CH2:18][C:16]=2[N:17]=1>>[CH3:12][C:13]1[S:14][C:15]2[CH2:21][CH:20]([CH2:22][O:23][S:7]([C:4]3[CH:5]=[CH:6][C:1]([CH3:11])=[CH:2][CH:3]=3)(=[O:9])=[O:8])[CH2:19][CH2:18][C:16]=2[N:17]=1

参加物

反応物 2

HCID 73974-Toluenesulfonyl chloride

HCID 129177502-Methyl-6-hydroxymethyl-4,5,6,7-tetrahydrobenzo[d]thiazole

生成物 1

HCID 129177612-Methyl-6-tosyloxymethyl-4,5,6,7-tetrahydrobenzo[d]thiazole収率 71%

実験手順

The compound is prepared by action of p-toluenesulfonyl chloride on the above derivative (IV) according to the procedure described in Example 1. M.p.=70°-71° C. Yield: 71%.

出典と根拠

ORDレコード: ord-34a4179ae40342fb8463423659cd0244
出典データセット: uspto-grants-1982_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04337343

反応ノート

読み込み中…