HCID 53755671、化合物 → 3-(4-Chlorobenzoyl)-2-methylbenzene hexanoic acid

HRID 1157008ノート

反応式

HRID 1157008 の反応式
[H][H].[Cl:3][C:4]1[CH:26]=[CH:25][C:7]([C:8]([C:10]2[C:11]([CH3:24])=[C:12]([CH2:16][CH:17]=[CH:18][CH2:19][CH2:20][C:21]([OH:23])=[O:22])[CH:13]=[CH:14][CH:15]=2)=[O:9])=[CH:6][CH:5]=1>CO.[Ni]>[Cl:3][C:4]1[CH:5]=[CH:6][C:7]([C:8]([C:10]2[C:11]([CH3:24])=[C:12]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][C:21]([OH:23])=[O:22])[CH:13]=[CH:14][CH:15]=2)=[O:9])=[CH:25][CH:26]=1

参加物

5

反応物 2

HCID 53755671HCID 53755671、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 205344893-(4-Chlorobenzoyl)-2-methylbenzene hexanoic acid

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

Hydrogen was passed through a mixture of 16.27 g of 6-[3'-(4-chlorobenzoyl)-2'-methyl-phenyl]-hex-4-enoic acid in 80 ml of methanol and 16.3 g of Raney nickel and then the catalyst was filtered off. The methoanol was distilled from the filtrate and the residue was taken up in methylene chloride. The solution was dried, treated with activated carbon, filtered and evaporated to dryness to obtain, after crystallization from a 1-1 isorpopyl ether-petroleum ether mixture, 11.15 g of 6-[3'-(4-chlorobenzoyl)-2'-methyl-phenyl]-hexanoic acid melting at 82° C.

後処理

  1. filtrationthe catalyst was filtered off
  2. distillationThe methoanol was distilled from the filtrate
  3. customThe solution was dried
  4. additiontreated with activated carbon
  5. filtrationfiltered
  6. customevaporated to dryness
  7. customto obtain
  8. customafter crystallization from a 1-1 isorpopyl ether-petroleum ether mixture, 11.15 g of 6-[3'-(4-chlorobenzoyl)-2'-methyl-phenyl]-hexanoic acid melting at 82° C.

出典と根拠

ORDレコード
ord-077a4a3960cf4468a58083d413d2bbbf
出典データセット
uspto-grants-1982_06
特許番号
US04337353

反応ノート

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