HCID 53650040、化合物 → 3-(4-Chlorobenzoyl)-2-methylbenzene hexanoic acid

HRID 1157009ノート

反応式

HRID 1157009 の反応式
[Cl:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]([C:8]2[C:9]([CH3:22])=[C:10]([CH:14]=[CH:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20])[CH:11]=[CH:12][CH:13]=2)=[O:7])=[CH:4][CH:3]=1.[H][H]>C(O)C.[Pt]=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([C:8]2[C:9]([CH3:22])=[C:10]([CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20])[CH:11]=[CH:12][CH:13]=2)=[O:7])=[CH:23][CH:24]=1

参加物

5

反応物 2

HCID 53650040HCID 53650040、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 205344893-(4-Chlorobenzoyl)-2-methylbenzene hexanoic acid収率 79.5%

試薬・触媒・溶媒 2

HCID 82844Platinum oxide (PtO)触媒HCID 702Ethanol溶媒

実験手順

5.425 g of 6-[3'-(4-chlorobenzoyl)-2'-methyl-phenyl]-hex-5-enoic acid dissolved in 100 ml of ethanol in the presence of 110 mg of platinum oxide had hydrogen pased therethrough and then the catalyst was filtered off. The filtrate was evaporated to dryness and the residue was taken up in ether. The solution was treated with activated carbon, filtered and evaporated to dryness. The residue was crystallized from a 1:1 isopropyl ether-petroleum ether mixture to obtain 4.34 g of 6-[3'-(4-chlorobenzoyl)-2'-methyl-phenyl]-hexanoic acid melting at 82° C.

後処理

  1. filtrationthe catalyst was filtered off
  2. customThe filtrate was evaporated to dryness
  3. additionThe solution was treated with activated carbon
  4. filtrationfiltered
  5. customevaporated to dryness
  6. customThe residue was crystallized from a 1:1 isopropyl ether-petroleum ether mixture

出典と根拠

ORDレコード
ord-def883ec1ffd482b914d837b78f3bf2f
出典データセット
uspto-grants-1982_06
特許番号
US04337353

反応ノート

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