化工社化工社 化学情報印刷レポート · 研究参考用
3-(3,4-Dihydroxyphenyl)Prop-2-Enoic Acid → Acetoacetic Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(3,4-Dihydroxyphenyl)Prop-2-Enoic Acid | HCID 2518 | — |
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | Acetoacetic Acid | HCID 96 | — |
| 生成物 | 3-(3,4-Dihydroxyphenyl)Prop-2-Enoic Acid | HCID 2518 | — |
反応手順
In accordance with the above flowchart, 3,4-dihydroxycinnamic acid (1) is reacted with acetic anhydride in pyridine for 18-30 hours and then extracted with organic solvents, giving 3,4-dihydroxycinnamic acid, diacetate (2) which is further converted to the 3,4-dihydroxycinnamic acid chloride (3) by treatment with thionyl chloride in dimethylformamide at -20° to -18° C. for 30-90 minutes.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04337249 |
| 出典データセット | uspto-grants-1982_06 |
| ORD ID | ord-602d0fb017934ef19c0aecd7ceace79c |
| 出典メモ | uspto-grants-1982_06 |