Acetic Acid → Acetic acid 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydro-pyridazin-3-yloxy)-phenyl]-ethyl ester

HRID 1157229ノート

反応式

HRID 1157229 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:20][CH2:21][OH:22])[CH:5]=[C:6]([Cl:19])[C:7]=1[O:8][C:9]1[N:10]=[N:11][C:12](Cl)=[C:13]([CH:15]([CH3:17])[CH3:16])[CH:14]=1.[C:23]([O-])(=[O:25])[CH3:24].[Na+].C(O)(=[O:30])C>>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:20][CH2:21][O:22][C:23](=[O:25])[CH3:24])[CH:5]=[C:6]([Cl:19])[C:7]=1[O:8][C:9]1[CH:14]=[C:13]([CH:15]([CH3:17])[CH3:16])[C:12](=[O:30])[NH:11][N:10]=1

参加物

4

反応物 3

HCID 176Acetic AcidHCID 517045Sodium AcetateHCID 598345252-[3,5-Dichloro-4-(6-chloro-5-isopropyl-pyridazin-3-yloxy)-phenyl]-ethanol

生成物 1

HCID 59834524Acetic acid 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydro-pyridazin-3-yloxy)-phenyl]-ethyl ester収率 100%

反応条件

温度
114 °C

実験手順

A solution of 2-[3,5-dichloro-4-(6-chloro-5-isopropyl-pyridazin-3-yloxy)-phenyl]-ethanol (17) (500 mg, 1.38 mmol) in glacial acetic acid (5 mL) was treated with sodium acetate (230 mg, 2.8 mmol) and heated to 114° C. for 24 h. At this time, the reaction mixture was cooled to room temperature and was concentrated under vacuum. The resulting residue was diluted with methylene chloride (25 mL) and was washed with water (10 mL). The organic layer was separated and was washed with a saturated aqueous sodium bicarbonate solution (10 mL). The waters layers were combined and extracted with methylene chloride (10 mL). The organic layers were combined and dried with sodium sulfate, filtered, concentrated and dried under high vacuum overnight to afford acetic acid 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydro-pyridazin-3-yloxy)-phenyl]-ethyl ester (34) (531 mg, 100%) as a white solid; LRMS for C17H18Cl2N2O4 (M+) m/z=385 Molecular Weight=385.2500; Exact Mass=384.0644

後処理

  1. temperatureAt this time, the reaction mixture was cooled to room temperature
  2. concentrationwas concentrated under vacuum
  3. additionThe resulting residue was diluted with methylene chloride (25 mL)
  4. washwas washed with water (10 mL)
  5. customThe organic layer was separated
  6. washwas washed with a saturated aqueous sodium bicarbonate solution (10 mL)
  7. extractionextracted with methylene chloride (10 mL)
  8. dry with materialdried with sodium sulfate
  9. filtrationfiltered
  10. concentrationconcentrated
  11. customdried under high vacuum overnight

出典と根拠

ORDレコード
ord-5653e9ce0ee44a809c201560bcdd6e64
出典データセット
uspto-grants-2010_10
特許番号
US07807674B2

反応ノート

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