N-methyl-2-pyrrolidone → HCID 178493790、化合物
反応式
Cl.[CH3:2][O:3][C:4]1[CH:9]=[N:8][C:7]([O:10]C)=[C:6]2[NH:12][CH:13]=[CH:14][C:5]=12.CN1CCCC1=O>O>[OH:10][C:7]1[N:8]=[CH:9][C:4]([O:3][CH3:2])=[C:5]2[C:6]=1[NH:12][CH:13]=[CH:14]2参加物
4
反応条件
- 温度
- 90 °C
実験手順
To 4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridine hydrochloride (50 g) taken in 2 L 3-necked round bottom flask, 250 ml N-methyl-2-pyrolidinone was added followed by 8 ml of water, and was heated to 90° C. for about 4 hrs. The reaction mixture was cooled to room temperature, diluted with water (1 L) and the whole mixture was kept in cold room for about one hour. The resulting solid was collected by filtration, washed with cold water and dried in vacuum oven at 50° C. for 4 hrs to afford 7-hydroxyl-4-methoxy-6-azaindole as white solid.
後処理
- temperatureThe reaction mixture was cooled to room temperature
- filtrationThe resulting solid was collected by filtration
- washwashed with cold water
- customdried in vacuum oven at 50° C. for 4 hrs
出典と根拠
- ORDレコード
- ord-c722c929d6434091af2636e2d548bb34
- 出典データセット
- uspto-grants-2010_10
- 特許番号
- US07807671B2
反応ノート
読み込み中…