(R)-3-(5-chloroindole-2-carbonylamino)-3,4-dihydrocarbostyril → (S)-3-(5-chloroindole-2-carbonylamino)-3,4-dihydrocarbostyril

HRID 11575

反応式

HRID 11575 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([NH:13][C@@H:14]1[CH2:23][C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[NH:16][C:15]1=[O:24])=[O:12])=[CH:5]2.C(OC(N[C@@H]1CC2C(=CC=CC=2)NC1=O)=O)(C)(C)C>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([NH:13][C@H:14]1[CH2:23][C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[NH:16][C:15]1=[O:24])=[O:12])=[CH:5]2

参加物

3

反応物 2

HCID 9840862(R)-3-(5-chloroindole-2-carbonylamino)-3,4-dihydrocarbostyril2 回HCID 69198597(R)-3-t-butyloxycarbonylamino-3,4-dihydrocarbostyril

生成物 1

HCID 44357926(S)-3-(5-chloroindole-2-carbonylamino)-3,4-dihydrocarbostyril

実験手順

The title compound was prepared from (S)-3-t-butyloxycarbonylamino-3,4-dihydrocarbostyril (prepared in Example 5) by the procedures described for the preparation of (R)-3-(5-chloroindole-2-carbonylamino)-3,4-dihydrocarbostyril (Example 5) from (R)-3-t-butyloxycarbonylamino-3,4-dihydrocarbostyril. HPLC/MS [M+H]+, 340; [M+Na]+, 362.

出典と根拠

ORDレコード
ord-2512700fc8144e54b4578077e1a943bc
出典データセット
uspto-grants-2006_08
特許番号
US07098235B2

関連ノート

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