HCID 59511390、化合物 → HCID 57737183、化合物
反応式
Cl[C:2]1[N:7]=[C:6]([C:8]2[C:9]([C:17]3[CH:18]=[C:19]([NH:23][C:24](=[O:29])[C:25]([F:28])([F:27])[F:26])[CH:20]=[CH:21][CH:22]=3)=[N:10][N:11]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=23)[CH:5]=[CH:4][N:3]=1.[CH3:30][O:31][C:32]1[CH:38]=[CH:37][C:35]([NH2:36])=[CH:34][C:33]=1[N:39]1[CH2:44][CH2:43][N:42]([CH2:45][CH2:46][S:47]([CH3:50])(=[O:49])=[O:48])[CH2:41][CH2:40]1>>[F:26][C:25]([F:28])([F:27])[C:24]([NH:23][C:19]1[CH:20]=[CH:21][CH:22]=[C:17]([C:9]2[C:8]([C:6]3[CH:5]=[CH:4][N:3]=[C:2]([NH:36][C:35]4[CH:37]=[CH:38][C:32]([O:31][CH3:30])=[C:33]([N:39]5[CH2:44][CH2:43][N:42]([CH2:45][CH2:46][S:47]([CH3:50])(=[O:49])=[O:48])[CH2:41][CH2:40]5)[CH:34]=4)[N:7]=3)=[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][N:11]3[N:10]=2)[CH:18]=1)=[O:29]参加物
3
実験手順
The compound was synthesized from N-{3-[3-(2-chloro-4-pyrimidinyl)-pyrazolo[1,5-a]pyridin-2-yl]phenyl}-2,2,2-trifluoroacetamide (see Example 1, Step C) and 4-(methyloxy)-3-{4-[2-(methylsulfonyl)ethyl]-1-piperazinyl}aniline to afford a yellow solid in 42% yield. ES-LC/MS m/z 695 [M+H]+.
後処理
- customto afford a yellow solid in 42% yield