Cesium carbonate → 4-{1-Methyl-2-[2-(2-(r)-methyl-pyrrolidin-1-yl)-ethyl]-1h-indol-5-yl}-benzonitrile

HRID 1157723

反応式

HRID 1157723 の反応式
C([O-])([O-])=O.[Cs+].[Cs+].[F-].[Cs+].[C:9]([C:11]1[CH:16]=[CH:15][C:14](B(O)O)=[CH:13][CH:12]=1)#[N:10].Br[C:21]1[CH:22]=[C:23]2[C:27](=[CH:28][CH:29]=1)[N:26]([CH3:30])[C:25]([CH2:31][CH2:32][N:33]1[CH2:37][CH2:36][CH2:35][CH:34]1[CH3:38])=[CH:24]2>C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.C1C=CC(/C=C/C(/C=C/C2C=CC=CC=2)=O)=CC=1.[Pd].[Pd].C1(C)C=CC=CC=1.O>[CH3:30][N:26]1[C:27]2[C:23](=[CH:22][C:21]([C:14]3[CH:15]=[CH:16][C:11]([C:9]#[N:10])=[CH:12][CH:13]=3)=[CH:29][CH:28]=2)[CH:24]=[C:25]1[CH2:31][CH2:32][N:33]1[CH2:37][CH2:36][CH2:35][C@H:34]1[CH3:38]

参加物

8

反応物 4

HCID 10796Cesium carbonateHCID 25953Cesium fluorideHCID 27343264-Cyanophenylboronic acidHCID 219799955-Bromo-1-methyl-2-[2-(2-methyl-pyrrolidin-1-yl)-ethyl]-1H-indole2 回

生成物 1

HCID 113023334-{1-Methyl-2-[2-(2-(r)-methyl-pyrrolidin-1-yl)-ethyl]-1h-indol-5-yl}-benzonitrile収率 44.8%

試薬・触媒・溶媒 3

HCID 9811564Bis(dibenzylideneacetone)palladium触媒HCID 962Water溶媒HCID 1140Toluene溶媒

反応条件

温度
65 °C

実験手順

A reaction flask was charged with Cs2CO3 (1.14 g, 3.5 mmol), CsF (0.38 g, 2.5 mmol), 4-cyanophenylboronic acid (425 mg, 2.5 mmol), and H2O (10 mL) followed by a toluene solution (10 mL) of 5-bromo-1-methyl-2-[2-(2-methyl-pyrrolidin-1-yl)-ethyl]-1H-indole (320 mg, 1.0 mmol). The resulting mixture was purged with nitrogen. To the reaction mixture was then added Cy2PPh2(5-bromo-2-[2-(R)-methyl-pyrrolidin-1-yl)-ethyl]-1H-indole) (35 mg, 0.1 mmol) and Pd2(dba)3 (46 mg, 0.05 mmol). The resulting reaction mixture was then heated to 65° C. overnight under nitrogen. HPLC indicated that all of the 5-bromo-1-methyl-2-[2-(2-methyl-pyrrolidin-1-yl)-ethyl]-1H-indole was consumed. The reaction mixture was cooled to room temperature and IPAc (20 mL) was added. The organic layer was separated and concentrated. The residue was purified by column chromatograph eluting with heptane/acetone/CH2Cl2/Et3N (600 mL/40 mL/5 mL/2 mL). The fractions containing product were combined and concentrated under reduced pressure to provide the title compound as a semi-solid (154 mg). 1H NMR (400 MHz, CDCl3) δ 7.57-7.66 (m, 5H), 7.30 (dd, J=1.7, 8.6 Hz, 1H), 7.25 (d, J=8.51 Hz, 1H), 6.27 (S, 1H), 3.63 (S, 1H), 3.21-3.25 (m, 1H), 3.06-3.13 (m, 1H), 2.87-2.93 (m, 2H), 2.33-2.40 (m, 2H), 2.16 (q, J=8.78 Hz, 1H), 1.84-1.91 (m, 1H), 1.65-1.76 (m, 2H), 1.36-1.44 (m, 1H), 1.07 (d, J=6.1 Hz, 3H). 13C NMR (400 MHz, CDCl3) δ 146.80, 140.39, 137.11, 132.04, 130.19, 128.11, 127.27, 119.86, 119.08, 118.43, 109.18, 99.37, 60.15, 54.19, 53.24, 32.89, 29.91, 26.85, 21.98, 19.32. [M+H]+ at m/z 344.

後処理

  1. customThe resulting mixture was purged with nitrogen
  2. customThe resulting reaction mixture
  3. customwas consumed
  4. temperatureThe reaction mixture was cooled to room temperature
  5. additionIPAc (20 mL) was added
  6. customThe organic layer was separated
  7. concentrationconcentrated
  8. customThe residue was purified by column chromatograph
  9. washeluting with heptane/acetone/CH2Cl2/Et3N (600 mL/40 mL/5 mL/2 mL)
  10. additionThe fractions containing product
  11. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-d8ad74b5c7bd4a5b9f0d20fb1cd22dfb
出典データセット
uspto-grants-2010_10
特許番号
US07807697B2

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