Potassium Carbonate → 3'-(4-Bromo-butoxy)-3,4-methylenedioxy-chalcone

関与物質

反応手順

This compound (41) was prepared from 3′-hydroxy-3,4-methylenedioxy-chalcone, 12 (2.7 g, 10 mmol), dibromo butane (3.6 mL, 30 mmol) and potassium carbonate (2.76 g, 20 mmol) in dry acetone (100 mL) using the identical procedure as described for 39. Yield 3.6 g (89%); mp 97-98° C.; MS (FAB) 403/405 (M++1); IR (KBr) 1654; 1H NMR (200 MHz, CDCl3) δ 7.73 (d, J=15.6 Hz, 1H), 7.58 (d, J=7.6 Hz, 1H), 7.51 (s, 1H), 7.39 (t, J=7.8 Hz, 1H), 7.34 (d, J=15.6 Hz, 1H), 7.16 (s, 1H), 7.14-7.07 (m, 2H), 6.84 (d, J=7.9 Hz, 1H), 6.02 (s, 2H), 4.07 (t, J=5.6 Hz, 2H), 3.50 (t, J=6.3 Hz, 2H), 2.16-1.94 (m, 4H).

情報源と証拠