Potassium Carbonate → 3'-(5-Bromo-pentyloxy)-3,4-methylenedioxy-chalcone

HRID 1157988

反応式

HRID 1157988 の反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][CH:20]=1)[C:5](=[O:17])[CH:6]=[CH:7][C:8]1[CH:13]=[CH:12][C:11]2[O:14][CH2:15][O:16][C:10]=2[CH:9]=1.Br[C:22](Br)([CH2:25][CH3:26])[CH2:23][CH3:24].C(=O)([O-])[O-].[K+].[K+].[K+].[Br-:35]>CC(C)=O>[Br:35][CH2:24][CH2:23][CH2:22][CH2:25][CH2:26][O:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][CH:20]=1)[C:5](=[O:17])[CH:6]=[CH:7][C:8]1[CH:13]=[CH:12][C:11]2[O:14][CH2:15][O:16][C:10]=2[CH:9]=1

参加物

6

反応物 4

HCID 11430Potassium CarbonateHCID 253877Potassium BromideHCID 4662443'-Hydroxy-3,4-methylenedioxy chalcone2 回HCID 135557303,3-Dibromopentane

生成物 1

HCID 686436533'-(5-Bromo-pentyloxy)-3,4-methylenedioxy-chalcone

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

This compound (42) was prepared from 3′-hydroxy-3,4-methylenedioxy-chalcone, 12 (2.7 g, 10 mmol), dibromo pentane (4.1 mL, 30 mmol) and potassium carbonate (2.76 g, 20 mmol) in dry acetone (100 mL) using the identical procedure as described for 39. Yield 2.7 g (64%); mp 87-88° C.; MS (FAB) 417/419 (M++1); IR (KBr) 1652; 1H NMR (200 MHz, CDCl3) δ 7.73 (d, J=15.6 Hz, 1H), 7.57 (d, J=7.6 Hz, 1H), 7.51 (d, J=2.1 Hz, 1H), 7.39 (t, J=7.8 Hz, 1H), 7.34 (d, J=15.6 Hz, 1H), 7.16 (s, 1H), 7.14-7.10 (m, 2H), 6.02 (s, 2H), 4.05 (t, J=6.2 Hz, 2H), 3.50 (t, J=6.7 Hz, 2H), 2.02-1.78 (m, 4H), 1.71-1.59 (m, 2H).

出典と根拠

ORDレコード
ord-4f2be69d2a44483092d931a3e2c807e5
出典データセット
uspto-grants-2010_10
特許番号
US07807712B2

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