Fluorobenzene → 4-Fluoro-4'-(phenylethynyl)benzophenone

HRID 1158547

反応式

HRID 1158547 の反応式
Br[C:2]1[CH:16]=[CH:15][C:5]([C:6]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1.F[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.Br[C:25]1C=CC(C(Cl)=O)=C[CH:26]=1.[Cl-].[Al+3].[Cl-].[Cl-]>>[F:14][C:11]1[CH:12]=[CH:13][C:8]([C:6]([C:5]2[CH:15]=[CH:16][C:2]([C:25]#[C:26][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:3][CH:4]=2)=[O:7])=[CH:9][CH:10]=1

参加物

5

反応物 4

HCID 10008FluorobenzeneHCID 685154-Bromobenzoyl chlorideHCID 74951(4-Bromophenyl)(4-fluorophenyl)methanoneHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 40956574-Fluoro-4'-(phenylethynyl)benzophenone

実験手順

4-bromo-4′-fluorobenzophenone: fluorobenzene (6.89 g, 71.7 mmol), 4-bromobenzoyl chloride (7.86 g, 35.8 mmol), and aluminum chloride (4.78 g, 35.8 mmol) were combined and stirred for 24 h at room temperature. The resulting mixture was poured over ice, and then filtered. The solid was dissolved in hot ethanol, treated with decolorizing charcoal, and filtered; white crystals of the title compound formed upon cooling of the ethanol solution and were isolated by filtration.

後処理

  1. additionThe resulting mixture was poured over ice
  2. filtrationfiltered
  3. dissolutionThe solid was dissolved in hot ethanol
  4. additiontreated with decolorizing charcoal
  5. filtrationfiltered

出典と根拠

ORDレコード
ord-791b65999ffc4c9597c9fd8e1a11e6c2
出典データセット
uspto-grants-2010_10
特許番号
US07811499B2

関連ノート

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