2-Bromopropane → tert-butyl {(1S)-2-[2-amino-3-(aminocarbonyl)-9h-pyrido[2,3-b]indol-9-yl]-1-methylethyl}carbamate

HRID 1158745

反応式

HRID 1158745 の反応式
[NH2:1][C:2]1[C:3]([C:18]([NH2:20])=[O:19])=[CH:4][C:5]2[C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[N:7](C(C)C)[C:6]=2[N:17]=1.I[CH2:22][C@@H:23]([NH:25][C:26](=[O:32])[O:27][C:28]([CH3:31])([CH3:30])[CH3:29])[CH3:24].BrC(C)C>C(O)=O>[C:28]([O:27][C:26](=[O:32])[NH:25][C@@H:23]([CH3:22])[CH2:24][N:7]1[C:8]2[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:5]2[CH:4]=[C:3]([C:18]([NH2:20])=[O:19])[C:2]([NH2:1])=[N:17][C:6]1=2)([CH3:31])([CH3:30])[CH3:29]

参加物

5

反応物 3

HCID 63582-BromopropaneHCID 15529790(S)-(2-Iodo-1-methyl-ethyl)-carbamic acid tert-butyl esterHCID 249006762-amino-9-isopropyl-9H-pyrido[2,3-b]indole-3-carboxamide

生成物 1

HCID 59513639tert-butyl {(1S)-2-[2-amino-3-(aminocarbonyl)-9h-pyrido[2,3-b]indol-9-yl]-1-methylethyl}carbamate

試薬・触媒・溶媒 1

HCID 284Formic Acid溶媒

実験手順

tert-butyl{(1S)-2-[2-amino-3-(aminocarbonyl)-9H-pyrido[2,3-b]indol-9-yl]-1-methylethyl}carbamate (xvi-b) was prepared following the procedure detailed in the synthesis of 13 substituting tert-butyl [(1S)-2-iodo-1-methylethyl]carbamate for 2-bromopropane. HCOOH Standard Conditions. M+H=384. 1H NMR (300 MHz, d6-DMSO): δ 8.71 (s, 1H), 7.77 (d, J=7.3 Hz, 1H), 7.59 (d, J=7.9 Hz, 1H), 7.57-7.49 (br s, 2H), 7.31 (dd, J=7.9, 7.3 Hz, 1H), 7.16 (dd, J=7.9, 7.3 Hz, 1H), 6.90 (br d, 1H), 4.27 (dd, J=6.1, 13.4 Hz, 1H), 4.14-3.95 (m, 2H), 1.18 (s, 9H), 1.05 (d, J=6.1 Hz, 3

出典と根拠

ORDレコード
ord-5dfe036fb1f1471688e713945faa7781
出典データセット
uspto-grants-2010_10
特許番号
US07812018B2

関連ノート

読み込み中…