Ammonium Chloride → 5-amino-1-methyl-3,6-dihydro-1H-pyrazin-2-one hydrochloride

HRID 1158864ノート

反応式

HRID 1158864 の反応式
CO[C:3]1[CH2:8][N:7]([CH3:9])[C:6](=[O:10])[CH2:5][N:4]=1.[Cl-:11].[NH4+:12]>C(O)C>[ClH:11].[NH2:12][C:3]1[CH2:8][N:7]([CH3:9])[C:6](=[O:10])[CH2:5][N:4]=1

参加物

4

反応物 2

HCID 25517Ammonium ChlorideHCID 219414705-methoxy-1-methyl-3,6-dihydro-1H-pyrazin-2-one

生成物 1

HCID 219413655-amino-1-methyl-3,6-dihydro-1H-pyrazin-2-one hydrochloride

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 5-methoxy-1-methyl-3,6-dihydro-1H-pyrazin-2-one (2.3 g) and ammonium chloride (936 mg) in dry ethanol (32 mL) was stirred at room temperature for 1 h and then refluxed for 2 h. The reaction mixture was cooled to room temperature and evaporated under reduced pressure. The residue was triturated with chloroform at room temperature for 30 min. The precipitate was filtered off and dried in vacuo. The 5-amino-1-methyl-3,6-dihydro-1H-pyrazin-2-one hydrochloride was obtained as a pale brown powder (1.7 g, 66%).

後処理

  1. temperaturerefluxed for 2 h
  2. temperatureThe reaction mixture was cooled to room temperature
  3. customevaporated under reduced pressure
  4. customThe residue was triturated with chloroform at room temperature for 30 min
  5. filtrationThe precipitate was filtered off
  6. customdried in vacuo

出典と根拠

ORDレコード
ord-3c39366ceb154f6bb335e0b81a8b86bf
出典データセット
uspto-grants-2010_10
特許番号
US07812014B2

反応ノート

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