Potassium Carbonate → 5-Amino-1-methyl-1,6-dihydropyrazin-2(3H)-one

HRID 1158865ノート

反応式

HRID 1158865 の反応式
Cl.[NH2:2][C:3]1[CH2:8][N:7]([CH3:9])[C:6](=[O:10])[CH2:5][N:4]=1.C(=O)([O-])[O-].[K+].[K+]>CO>[NH2:2][C:3]1[CH2:8][N:7]([CH3:9])[C:6](=[O:10])[CH2:5][N:4]=1

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 219413655-amino-1-methyl-3,6-dihydro-1H-pyrazin-2-one hydrochloride

生成物 1

HCID 219413665-Amino-1-methyl-1,6-dihydropyrazin-2(3H)-one

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 5-amino-1-methyl-3,6-dihydro-1H-pyrazin-2-one hydrochloride (662 mg) in methanol (10 mL) was added 10% potassium carbonate aqueous solution at 0° F. and then stirred for 40 min at 0□. The mixture was concentrated under reduced pressure. The residue was triturated with chloroform (18 mL) and methanol (2 mL) at room temperature for 30 min. The precipitate was filtered off and dried in vacuo. The compound was obtained as a pale brown powder (515 mg, quantitative).

後処理

  1. concentrationThe mixture was concentrated under reduced pressure
  2. customThe residue was triturated with chloroform (18 mL) and methanol (2 mL) at room temperature for 30 min
  3. filtrationThe precipitate was filtered off
  4. customdried in vacuo
  5. customThe compound was obtained as a pale brown powder (515 mg, quantitative)

出典と根拠

ORDレコード
ord-30ab975d9433465aa82428a1b34e4dd5
出典データセット
uspto-grants-2010_10
特許番号
US07812014B2

反応ノート

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