HCID 58636874、化合物 → Ammonium Hydroxide
反応式
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH2:11][C:12]2[C:13]([CH2:20][NH:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][C:27]([OH:29])=[O:28])=[C:14]([OH:19])[C:15]([CH3:18])=[N:16][CH:17]=2)=[CH:6][CH:5]=1)(=[NH:3])[NH2:2]>Cl>[OH-:19].[NH4+:2].[CH2:1]([O:19][C:14]1[C:15]([CH3:18])=[N:16][CH:17]=[C:12]([CH2:11][NH:10][C:7]2[CH:6]=[CH:5][C:4]([C:1](=[NH:2])[NH2:3])=[CH:9][CH:8]=2)[C:13]=1[CH2:20][NH:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][C:27]([OH:29])=[O:28])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1参加物
4
実験手順
The hydrolysis of 6-({5-[(4-carbamimidoyl-phenylamino)-methyl]-3-hydroxy-2-methyl-pyridin-4 ylmethyl}-amino)-hexanoic acid (49) (100 mg, 0.2 mmol) was carried out in 6N hydrochloric acid for 2 hours. The solvent was then evaporated and the crude product purified by column chromatography on silica gel using a mixture of dichloromethane:methyl alcohol:30% ammonium hydroxide (5:3:1) as eluant to give 6-({3-benzyloxy-5-[(4-carbamimidoyl-phenylamino)-methyl]-2-methyl-pyridin-4-ylmethyl}-amino)-hexanoic acid (50).