2-Butanamine, 2-methyl- → 2-bromo-N-(1,1-dimethylpropyl)benzenesulfonamide
反応式
[CH3:1][C:2]([NH2:6])([CH2:4][CH3:5])[CH3:3].[Br:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[S:14](Cl)(=[O:16])=[O:15]>ClCCl>[Br:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[S:14]([NH:6][C:2]([CH3:3])([CH3:1])[CH2:4][CH3:5])(=[O:16])=[O:15]参加物
4
実験手順
To a solution of 2-methyl-2-butanamine (11.4 mL, 97.8 mmol) in dichloromethane (100 mL) was added, dropwise over a 10 min period, a solution of 2-bromobenzenesulfonyl chloride (10.0 g, 39.1 mmol) in dichloromethane (ca. 50 mL). After stirring for 15 h the reaction was concentrated in vacuo. The residue was crystallized from methyl t-butyl ether to provide 10.5 g (87%) of 2-bromo-N-(1,1-dimethylpropyl)benzenesulfonamide in two crops: LCMS (neg. ion spectrum) m/z 304/306.
後処理
- concentrationwas concentrated in vacuo
- customThe residue was crystallized from methyl t-butyl ether
出典と根拠
- ORDレコード
- ord-a477453affbe4a15aebc4fa4448c4b7b
- 出典データセット
- uspto-grants-2010_10
- 特許番号
- US07812024B2
反応ノート
読み込み中…