1-Bromo-2-propanol → 3-[1-(2-hydroxypropyl)piperidin-4-yl]-2H-isoquinolin-1-one

反応式

Cl.[NH:2]1[CH2:7][CH2:6][CH:5]([C:8]2[NH:9][C:10](=[O:18])[C:11]3[C:16]([CH:17]=2)=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH2:4][CH2:3]1.Br[CH2:20][CH:21]([OH:23])[CH3:22]>>[OH:23][CH:21]([CH3:22])[CH2:20][N:2]1[CH2:7][CH2:6][CH:5]([C:8]2[NH:9][C:10](=[O:18])[C:11]3[C:16]([CH:17]=2)=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH2:4][CH2:3]1

参加物

反応物 2

HCID 297401-Bromo-2-propanol

HCID 230821133-(Piperidin-4-yl)isoquinolin-1(2H)-one hydrochloride

生成物 1

HCID 103341973-[1-(2-hydroxypropyl)piperidin-4-yl]-2H-isoquinolin-1-one収率 16.1%

実験手順

By the reaction in the same manner as in Example 2a, using 3-(piperidin-4-yl)-2H-isoquinolin-1-one hydrochloride (500 mg) and 1-bromo-2-propanol (394 mg), 3-[1-(2-hydroxypropyl)piperidin-4-yl]-2H-isoquinolin-1-one (87 mg) was obtained.

後処理

customBy the reaction in the same manner as in Example 2a

出典と根拠

ORDレコード: ord-db44da306ebc4b3887588cce2ea89f06
出典データセット: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07812178B2

反応ノート

読み込み中…

参加物