Phosphorus tribromide → 1-(Bromomethyl)-2,4-dimethylbenzene

HRID 1159643

反応式

HRID 1159643 の反応式
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[CH2:9]O.P(Br)(Br)[Br:12]>CCOCC>[Br:12][CH2:9][C:3]1[CH:4]=[CH:5][C:6]([CH3:8])=[CH:7][C:2]=1[CH3:1]

参加物

4

反応物 2

HCID 24614Phosphorus tribromideHCID 278092,4-Dimethylbenzyl alcohol

生成物 1

HCID 27346041-(Bromomethyl)-2,4-dimethylbenzene

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

反応条件

温度
0 °C

実験手順

5 g of (2,4-dimethylphenyl)methanol are dissolved in 100 ml of ether. The reaction mixture is cooled to 0° C. It is admixed dropwise with 5.2 ml of phosphorus tribromide. It is stirred at ambient temperature overnight. The reaction mixture is poured onto ice and extracted with AcOEt. The organic phase is washed with saturated NaCl solution. The organic phase is dried over MgSO4, filtered and evaporated to dryness. This gives 7.3 g of the expected compound.

後処理

  1. additionThe reaction mixture is poured onto ice
  2. extractionextracted with AcOEt
  3. washThe organic phase is washed with saturated NaCl solution
  4. dry with materialThe organic phase is dried over MgSO4
  5. filtrationfiltered
  6. customevaporated to dryness

出典と根拠

ORDレコード
ord-d73d118dd0614b2d8413423dd397717a
出典データセット
uspto-grants-2010_10
特許番号
US07812165B2

関連ノート

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