Phosphorus tribromide → 1-(Bromomethyl)-2,4-dimethylbenzene
反応式
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[CH2:9]O.P(Br)(Br)[Br:12]>CCOCC>[Br:12][CH2:9][C:3]1[CH:4]=[CH:5][C:6]([CH3:8])=[CH:7][C:2]=1[CH3:1]参加物
4
反応条件
- 温度
- 0 °C
実験手順
5 g of (2,4-dimethylphenyl)methanol are dissolved in 100 ml of ether. The reaction mixture is cooled to 0° C. It is admixed dropwise with 5.2 ml of phosphorus tribromide. It is stirred at ambient temperature overnight. The reaction mixture is poured onto ice and extracted with AcOEt. The organic phase is washed with saturated NaCl solution. The organic phase is dried over MgSO4, filtered and evaporated to dryness. This gives 7.3 g of the expected compound.
後処理
- additionThe reaction mixture is poured onto ice
- extractionextracted with AcOEt
- washThe organic phase is washed with saturated NaCl solution
- dry with materialThe organic phase is dried over MgSO4
- filtrationfiltered
- customevaporated to dryness
出典と根拠
- ORDレコード
- ord-d73d118dd0614b2d8413423dd397717a
- 出典データセット
- uspto-grants-2010_10
- 特許番号
- US07812165B2
反応ノート
読み込み中…