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Ethylamine → N'-[4-(1,2,2,6,6-Pentamethyl-piperidin-4-ylcarbamoyl)-phenyl]-hydrazinecarboxylic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethylamine | HCID 6341 | — |
| 反応物 | 4-Amino-1,2,2,6,6-pentamethylpiperidine | HCID 693792 | — |
| 反応物 | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| 反応物 | 4-(2-(tert-Butoxycarbonyl)hydrazinyl)benzoic acid | HCID 2755984 | — |
| 溶媒 | Dimethylacetamide | HCID 31374 | — |
| 生成物 | N'-[4-(1,2,2,6,6-Pentamethyl-piperidin-4-ylcarbamoyl)-phenyl]-hydrazinecarboxylic acid tert-butyl ester | HCID 59515583 | — |
反応手順
To a solution of 4-(N′-tert-Butoxycarbonyl-hydrazino)-benzoic acid (4.452 g) in DMA (30 ml) was added disopropyl ethyl amine (6.16 ml) and HBTU (6.69 g) with stirring at room temp. 4-Amino-1,2,2,6,6-pentamethylpiperidine (3 g) was then added to the stirred solution. Stirring continued at room temp for 4 hrs.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07816361B2 |
| 出典データセット | uspto-grants-2010_10 |
| ORD ID | ord-bea97ea435f440fe82eb8e6b2adb9c14 |
| 出典メモ | uspto-grants-2010_10 |