Sodium ethoxide → 3-Furan-2-yl-2,2-dimethyl-3-oxo-propionic acid ethyl ester

HRID 1160137ノート

反応式

HRID 1160137 の反応式
[CH2:1]([O:3][C:4](=[O:14])[CH:5]([CH3:13])[C:6]([C:8]1[O:9][CH:10]=[CH:11][CH:12]=1)=[O:7])[CH3:2].[O-][CH2:16]C.[Na+]>C(O)C>[CH2:1]([O:3][C:4](=[O:14])[C:5]([CH3:16])([CH3:13])[C:6]([C:8]1[O:9][CH:10]=[CH:11][CH:12]=1)=[O:7])[CH3:2]

参加物

4

反応物 2

HCID 2723922Sodium ethoxideHCID 12143105Ethyl 3-(furan-2-yl)-2-methyl-3-oxopropanoate

生成物 1

HCID 595155823-Furan-2-yl-2,2-dimethyl-3-oxo-propionic acid ethyl ester

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

3-furan-2-yl-2-methyl-3-oxo-propionic acid ethyl ester (49 mg) was added sodium ethoxide (0.22 ml) and 0.5 ml ethanol. A solid precipitates. The solution was stirred at room temperature for 1 h, iodomethane was added and the suspension stirred at room temperature for 3 h. Concentration in vacuo and purification by HPLC gave the expected product.

後処理

  1. customA solid precipitates
  2. additioniodomethane was added
  3. stirringthe suspension stirred at room temperature for 3 h
  4. concentrationConcentration
  5. customin vacuo and purification by HPLC

出典と根拠

ORDレコード
ord-784064109788427a89aed41f60ec632b
出典データセット
uspto-grants-2010_10
特許番号
US07816361B2

反応ノート

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