反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][C:8]([O:10][CH2:11]C)=[O:9].CO[CH:15](OC)[N:16]([CH3:18])[CH3:17].[NH4+].[Cl-]>CCOC(C)=O>[CH3:15][N:16]([CH3:18])[CH:17]=[C:7]([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=1)[C:8]([O:10][CH3:11])=[O:9]参加物
5
反応条件
- 温度
- 130 °C
実験手順
10 g of ethyl 2-(2-pyridinyl)acetate, 39 ml of dimethoxy-N,N-dimethylmethanamine and 1.5 ml of N,N,N′,N′-tetramethylenediamine are mixed and the mixture is heated at 130° C. for 18 hours. The mixture is taken up in 120 ml of a mixture of equal volumes of AcOEt and of a saturated NH4Cl solution. The organic phase is separated by settling, washed with a saturated NaCl solution, dried over Na2SO4 and evaporated to produce the expected product in the form of an oil.
後処理
- customThe organic phase is separated
- washwashed with a saturated NaCl solution
- dry with materialdried over Na2SO4
- customevaporated
出典と根拠
- ORDレコード
- ord-1653dbe7e59742519c502e2e7620dcb8
- 出典データセット
- uspto-grants-2010_10
- 特許番号
- US07816368B2
関連ノート
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