5-(Methylthio)-2-nitroaniline → HCID 20393009、化合物

HRID 1160168

反応式

HRID 1160168 の反応式
[CH3:1][S:2][C:3]1[CH:4]=[CH:5][C:6]([N+:10]([O-])=O)=[C:7]([CH:9]=1)[NH2:8]>C(O)(=O)C.[Zn]>[CH3:1][S:2][C:3]1[CH:4]=[CH:5][C:6]([NH2:10])=[C:7]([NH2:8])[CH:9]=1

参加物

4

反応物 1

HCID 105354825-(Methylthio)-2-nitroaniline

生成物 1

HCID 20393009HCID 20393009、化合物収率 100.9%

試薬・触媒・溶媒 2

HCID 23994Zinc触媒HCID 176Acetic Acid溶媒

反応条件

温度
85 °C

実験手順

A solution of 5-methylthio-2-nitroaniline (50 mg; 0.27 mmol) in acetic acid (2 ml) was heated to 85° C. Zinc powder (71 mg; 1.09 mmol) was then added portionwise over 15 minutes and the resulting solution was maintained at 85° C. for 2 hours. The hot reaction mixture was then filtered through celite and the filter cake washed with hot acetic acid (10 ml). The filtrate was evaporated to dryness to give crude 4-methylthio-1,2-phenylenediamine (42 mg, 100%). This was used directly in the next step without purification.

後処理

  1. filtrationThe hot reaction mixture was then filtered through celite
  2. washthe filter cake washed with hot acetic acid (10 ml)
  3. customThe filtrate was evaporated to dryness

出典と根拠

ORDレコード
ord-680012fb0c2e4520b00d0e1c4239d0ee
出典データセット
uspto-grants-2010_10
特許番号
US07816369B2

関連ノート

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