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Ethyl bromoacetate → 2-Trifluromethyl-4-nitrophenoxyacetic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl bromoacetate | HCID 7748 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Phenol, 4-nitro-2-(trifluoromethyl)- | HCID 3014014 | — |
| 溶媒 | Methyl Ethyl Ketone | HCID 6569 | — |
| 生成物 | 2-Trifluromethyl-4-nitrophenoxyacetic acid ethyl ester | HCID 19261608 | 95% |
反応手順
A mixture of 2-trifluoromethyl-4-nitrophenol (73.4 g, 0.354 mol), ethyl bromoacetate (65.2 g, 0.39 mol), potassium carbonate (58.7 g, 0.425 mol) and 2-butanone (400 mL) was refluxed under stirring for 10 h. The solid was filtered off, the filtrate was evaporated and the residue was fractionated yielding 97.8 g (95%) of 2-trifluromethyl-4-nitrophenoxyacetic acid ethyl ester, b.p. 126° C./40 Pa.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07816385B2 |
| 出典データセット | uspto-grants-2010_10 |
| ORD ID | ord-79e7ca7fc78b4de0abd00959d8e0b2bc |
| 出典メモ | uspto-grants-2010_10 |