HCID 68535377、化合物 → HCID 23028125、化合物
反応式
[Cl:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][C:7]([CH:10]=[CH:11][CH3:12])=[N:6][N:5]2[C:13]=1[S:14]([N:17]=CN(CC(C)C)CC(C)C)(=[O:16])=[O:15].ClC1N=C2C=CC(C3CC3)=NN2C=1S(N=CN(CC(C)C)CC(C)C)(=O)=O>>[Cl:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][C:7](/[CH:10]=[CH:11]/[CH3:12])=[N:6][N:5]2[C:13]=1[S:14]([NH2:17])(=[O:15])=[O:16]参加物
3
実験手順
The reaction was carried out in the same manner as in Reference Example 12 except that N′-(2-chloro-6-(1-propenyl)imidazo[1,2-b]pyridazin-3-ylsulfonyl)-N,N-diisobutylformamidine as a mixture of E and Z was used in place of N′-(2-chloro-6-cyclopropylimidazo[1,2-b]pyridazin-3-ylsulfonyl)-N,N-diisobutylformamidine. The resulting crystals were purified by silica gel column chromatography (chloroform:methanol=20:1), to give the title compound as white crystals. The yield was 70.1%.
後処理
- customThe resulting crystals were purified by silica gel column chromatography (chloroform:methanol=20:1)