7-Methylchroman-2-one → HCID 69655326、化合物

HRID 11609ノート

反応式

HRID 11609 の反応式
[F:1][C:2]1[CH:16]=[CH:15][C:5]([CH2:6][N:7]2[CH2:12][C@H:11]([CH3:13])[NH:10][CH2:9][C@H:8]2[CH3:14])=[CH:4][CH:3]=1.[CH3:17][C:18]1[CH:27]=[C:26]2[C:21]([CH2:22][CH2:23][C:24](=[O:28])[O:25]2)=[CH:20][CH:19]=1>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:16]=[CH:15][C:5]([CH2:6][N:7]2[C@@H:8]([CH3:14])[CH2:9][N:10]([C:24](=[O:28])[CH2:23][CH2:22][C:21]3[CH:20]=[CH:19][C:18]([CH3:17])=[CH:27][C:26]=3[OH:25])[C@H:11]([CH3:13])[CH2:12]2)=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 2276157-Methylchroman-2-oneHCID 23405839(2R,5S)-1-(4-fluorobenzyl)-2,5-dimethylpiperazine

生成物 1

HCID 69655326HCID 69655326、化合物収率 79%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a solution of (2R,5S)-1-(4-fluoro-benzyl)-2,5-dimethyl-piperazine (0.25 g, 1.12 mmol) in toluene (10 mL) was added 7-methyl-chroman-2-one (0.25 g, 1.54 mmol) and the resulting solution was heated to reflux for 48 hours. The reaction was cooled, concentrated in vacuo and purified via chromatography on silica gel to give the title compound (0.34 g).

後処理

  1. temperaturethe resulting solution was heated
  2. temperatureto reflux for 48 hours
  3. temperatureThe reaction was cooled
  4. concentrationconcentrated in vacuo
  5. custompurified via chromatography on silica gel

出典と根拠

ORDレコード
ord-60ca7772c831497391bbb6d09424b31d
出典データセット
uspto-grants-2006_08
特許番号
US07098212B2

反応ノート

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