1-Bromo-2,4,6-triisopropylbenzene → Racemic 3-{4-[1-(2,4,6-triisopropyl-phenoxy)-5,5,5-trifluoro-pentyl]-benzoylamino}-propionic acid
反応式
C[O:2][C:3](=[O:39])[CH2:4][CH2:5][NH:6][C:7](=[O:38])[C:8]1[CH:13]=[CH:12][C:11]([CH:14]([O:22]C2C=CC(B3OC(C)(C)C(C)(C)O3)=CC=2)[CH2:15][CH2:16][CH2:17][C:18]([F:21])([F:20])[F:19])=[CH:10][CH:9]=1.Br[C:41]1[C:46]([CH:47]([CH3:49])[CH3:48])=[CH:45][C:44]([CH:50]([CH3:52])[CH3:51])=[CH:43][C:42]=1[CH:53]([CH3:55])[CH3:54]>>[CH:53]([C:42]1[CH:43]=[C:44]([CH:50]([CH3:52])[CH3:51])[CH:45]=[C:46]([CH:47]([CH3:49])[CH3:48])[C:41]=1[O:22][CH:14]([C:11]1[CH:12]=[CH:13][C:8]([C:7]([NH:6][CH2:5][CH2:4][C:3]([OH:39])=[O:2])=[O:38])=[CH:9][CH:10]=1)[CH2:15][CH2:16][CH2:17][C:18]([F:21])([F:20])[F:19])([CH3:55])[CH3:54]参加物
3
反応物 2
生成物 1
実験手順
The title compound is prepared in a manner substantially similar to Example 359 starting from 3-(4-{5,5,5-trifluoro-1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenoxy]-pentyl}-benzoylamino)-propionic acid methyl ester and 2-bromo-1,3,5-triisopropyl-benzene. MS: 610.2 [M−H]−.
出典と根拠
- ORDレコード
- ord-715d64723eb4453caef50f3c516dc09e
- 出典データセット
- uspto-grants-2010_10
- 特許番号
- US07816557B2
反応ノート
読み込み中…