Methanol → (R)-2-(5-Nitro-1-oxoisoquinolin-2(1H)-yl)propanamide

HRID 1161202ノート

反応式

HRID 1161202 の反応式
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7]O[C:9]2=[O:14])([O-:3])=[O:2].CO.Cl.[NH2:18][C@H:19]([CH3:23])[C:20]([NH2:22])=[O:21].C(N(CC)CC)C>>[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:18]([C@H:19]([CH3:23])[C:20]([NH2:22])=[O:21])[C:9]2=[O:14])([O-:3])=[O:2]

参加物

5

反応物 4

HCID 887MethanolHCID 8471TriethylamineHCID 2775814(2R)-2-Aminopropanamide hydrochlorideHCID 100127605-nitro-1H-isochromen-1-one

生成物 1

HCID 59515648(R)-2-(5-Nitro-1-oxoisoquinolin-2(1H)-yl)propanamide

反応条件

温度
52 °C

実験手順

A round bottom flask was charged with 5-nitro-isochromen-1-one (2 g, 0.01 mol), methanol (40 mL, 1 mol), (R)-2-aminopropanamide hydrochloride (2.0 g, 0.016 mol) and triethylamine (2.6 mL, 0.019 mol) and stirred at 52° C. for 3 hours. The product (yellow solid) precipitated out which was filtered and carried on to the next reaction without any further purification. MS m/z=262.3 (M+H).

後処理

  1. customThe product (yellow solid) precipitated out which
  2. filtrationwas filtered
  3. customcarried on to the next reaction without any further purification

出典と根拠

ORDレコード
ord-f2b9a9fb4e054d3f82648fb9888f1267
出典データセット
uspto-grants-2010_10
特許番号
US07816371B2

反応ノート

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