Methanol → (S)-3-Hydroxy-2-(5-nitro-1-oxoisoquinolin-2(1H)-yl)propanamide
反応式
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7]O[C:9]2=[O:14])([O-:3])=[O:2].CO.Cl.[NH2:18][C@@H:19]([CH2:23][OH:24])[C:20]([NH2:22])=[O:21].C(N(CC)CC)C>>[OH:24][CH2:23][C@H:19]([N:18]1[CH:7]=[CH:6][C:5]2[C:10](=[CH:11][CH:12]=[CH:13][C:4]=2[N+:1]([O-:3])=[O:2])[C:9]1=[O:14])[C:20]([NH2:22])=[O:21]参加物
5
反応条件
- 温度
- 52 °C
実験手順
A round bottom flask was charged with 5-nitro-isochromen-1-one (2 g, 0.01 mol), methanol (40 mL, 1 mol), (S)-2-amino-3-hydroxypropanamide hydrochloride (2.2 g, 0.016 mol) and triethylamine (2.55 mL, 0.0183 mol) and stirred at 52° C. overnight. The product precipitated out and was filtered and dried to yield the pure product as a yellow solid. MS m/z=278.3 (M+H).