関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | 7-Bromobicyclo[2.2.1]heptane | HCID 565359 | — |
| 反応物 | Magnesium | HCID 5462224 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | Bicyclo[2.2.1]heptane-7-carbaldehyde | HCID 84647822 | 48.4% |
反応手順
15.9 g (81 mmol) of 7-Bromo-bicyclo[2.2.1]heptane were added dropwise to 2 g magnesium (81 mmol) in 25 ml of diethyl ether and refluxed for 2.5 h. The mixture was cooled to 0-5° C. and 6.3 ml (81 mmol) of DMF were added dropwise. The mixture was then refluxed for 2 h, cooled to room temperature and the white solid filtered off and washed with ether. The filtrate was reduced and 4.87 g of a white solid were obtained. The intermediate was used without further characterization.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07816540B2 |
|---|
| 出典データセット | uspto-grants-2010_10 |
|---|
| ORD ID | ord-3677f50506fc4935bf76f6977304ac04 |
|---|
| 出典メモ | uspto-grants-2010_10 |
|---|
