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Benzyl Bromide → 3-Benzyl-1-cyclohexylpyrrolidin-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzyl Bromide | HCID 7498 | — |
| 反応物 | N-Cyclohexyl-2-pyrrolidone | HCID 81278 | — |
| 反応物 | Lithium diisopropylamide | HCID 2724682 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 3-Benzyl-1-cyclohexylpyrrolidin-2-one | HCID 11673314 | 70% |
反応手順
Place 1-cyclohexyl-pyrrolidin-2-one (400 mg, 2.4 mmol) in THF (30 mL) and cool to −78° C. Slowly add LDA (2.0 M, 2.4 mL, 4.8 mmol) and stir for 15 minutes. Add benzyl bromide (1.23 g, 7.2 mmol) and stir for 3 hours. Quench with ammonium chloride and extract with dichloromethane. Dry over sodium sulfate, filter, and concentrate. Purify by silica gel (20-50% ethyl acetate in hexanes) to afford 432 mg (70%) of the title compound. Mass spectrum (apci) m/z=258.2 (M+H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07820659B2 |
| 出典データセット | uspto-grants-2010_10 |
| ORD ID | ord-8003b4837fe14b74a8a40c2e56c4f30b |
| 出典メモ | uspto-grants-2010_10 |