関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Toluene | HCID 1140 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Ethyl 2-bromopropionate | HCID 79040 | — |
| 反応物 | N1,N1-Dibenzylethane-1,2-diamine | HCID 6394114 | — |
| 生成物 | Ethyl 1,4-dibenzylpiperazine-2-carboxylate | HCID 2736402 | 96% |
反応手順
A solution of N,N-dibenzylethylenediamine (980 μL, 4.10 mmol) and triethylamine (1.03 mL, 7.38 mmol) in toluene (15 mL) was added dropwise to a solution of 2-bromopropionic acid ethyl ester (601 μL, 4.14 mmol) in toluene (15 mL). The reaction mixture was stirred at 80° C. for 72 h. The reaction mixture was filtered through a pad of celite and solvent evaporated under reduced pressure to afford 1,4-dibenzylpiperazine-2-carboxylic acid ethyl ester (1.33 g, 3.93 mmol, 96%) as a yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07820649B2 |
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| 出典データセット | uspto-grants-2010_10 |
|---|
| ORD ID | ord-38b6c756ab61492fbf41aaf05fc15f7e |
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| 出典メモ | uspto-grants-2010_10 |
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