3-Aminopiperidine-2,6-dione hydrochloride → 2-(2,6-Dioxo(3-piperidyl))-4-ethylisoindoline-1,3-dione

HRID 1162185

反応式

HRID 1162185 の反応式
[CH2:1]([C:3]1[CH:13]=[CH:12][CH:11]=[C:5]2[C:6]([O:8][C:9](=[O:10])[C:4]=12)=O)[CH3:2].Cl.[NH2:15][CH:16]1[CH2:21][CH2:20][C:19](=[O:22])[NH:18][C:17]1=[O:23].C([O-])(=O)C.[Na+]>C(O)(=O)C>[O:23]=[C:17]1[CH:16]([N:15]2[C:9](=[O:10])[C:4]3[C:5](=[CH:11][CH:12]=[CH:13][C:3]=3[CH2:1][CH3:2])[C:6]2=[O:8])[CH2:21][CH2:20][C:19](=[O:22])[NH:18]1

参加物

5

反応物 3

HCID 1345483-Aminopiperidine-2,6-dione hydrochlorideHCID 2841554-Ethyl-2-benzofuran-1,3-dioneHCID 517045Sodium Acetate

生成物 1

HCID 99258962-(2,6-Dioxo(3-piperidyl))-4-ethylisoindoline-1,3-dione

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

2-(2,6-Dioxo(3-piperidyl))-4-ethylisoindoline-1,3-dione was prepared by the procedure of Example 1 from 3-ethylphthalic anhydride (0.860 g, 4.89 mmol), 3-aminopiperidine-2,6-dione hydrogen chloride (0.803 g, 4.88 mmol) and sodium acetate (0.420 g, 5.12 mmol) in acetic acid (10 mL). The product was a white solid (1.06 g, 76% yield); mp, 235.0-236.5° C.; 1H NMR (DMSO-d6) δ 1.22 (t, J=7.4 Hz, 3H, CH3), 2.04-2.10 (m, 1H, CHH), 2.47-2.63 (m, 2H, CH2), 2.83-2.98 (m, 1H, CHH), 3.07 (q, J=7.5 Hz, 2H, CH2), 5.13 (dd, J=5.4, 12.5 Hz, 1H, NCH), 7.70-7.82 (m, 3H, Ar), 11.13 (br s, 1H, NH); 13C NMR (DMSO-d6) δ 14.84, 21.95, 23.69, 30.90, 48.77, 121.09, 127.26, 131.76, 134.63, 135.39, 143.87, 166.99, 167.58, 169.85, 172.72; Anal Calcd for C15H14N2O4: C, 62.93; H, 4.93; N, 9.79. Found: C, 62.74; H, 4.84; N, 9.54.

出典と根拠

ORDレコード
ord-b852121b3a8e4a85b5262c2a2985bafa
出典データセット
uspto-grants-2010_10
特許番号
US07820697B2

関連ノート

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