関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | N-(6-bromo-5H-imidazo[2,1-b][1,3]oxazin-2-yl)-2,2,2-trifluoroacetamide | HCID 91755269 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 6-Bromoimidazo[1,2-a]pyridin-2-amine | HCID 44119296 | 42% |
反応手順
To a 250 mL round-bottomed flask was added N-(6-bromoH-imidazo[1,2-a]pyridin-2-yl)-2,2,2-trifluoroacetamide (3.50 g, 11 mmol), THF (15 mL), methanol (15 mL), water (15 mL) and potassium carbonate (16 g, 114 mmol). The mixture was stirred at 60° C. for 16 h. After cooling to rt, the mixture was poured into water (100 mL) and extracted with CH2Cl2 (4×75 mL). The combined extracts were washed with brine, dried (Na2SO4) and concentrated onto silica. Purification by silica gel chromatography (0.5 to 5.0% MeOH/CH2Cl2) afforded the title compound (1.01 g, 42%). MS (ESI, positive ion) m/z: 212 (M(79Br)+1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07820665B2 |
|---|
| 出典データセット | uspto-grants-2010_10 |
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| ORD ID | ord-2348a1d85cd94beba1202cd661fc1e9a |
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| 出典メモ | uspto-grants-2010_10 |
|---|
