Hydrochloric Acid → [4-(4-Isopropyl-phenyl)-thiazol-2-ylsulfamoyl]-acetic acid
反応式
C([O:5][C:6](=[O:26])[CH2:7][S:8](=[O:25])(=[O:24])[NH:9][C:10]1[S:11][CH:12]=[C:13]([C:15]2[CH:20]=[CH:19][C:18]([CH:21]([CH3:23])[CH3:22])=[CH:17][CH:16]=2)[N:14]=1)(C)(C)C.Cl>O1CCOCC1>[CH:21]([C:18]1[CH:19]=[CH:20][C:15]([C:13]2[N:14]=[C:10]([NH:9][S:8]([CH2:7][C:6]([OH:26])=[O:5])(=[O:25])=[O:24])[S:11][CH:12]=2)=[CH:16][CH:17]=1)([CH3:23])[CH3:22]参加物
4
実験手順
[4-(4-Isopropyl-phenyl)-thiazol-2-ylsulfamoyl]-acetic acid tert-butyl ester was combined with 4M HCl in dioxane as in general procedure G1 to furnish [4-(4-Isopropyl-phenyl)-thiazol-2-ylsulfamoyl]-acetic acid. LCMS m/z: 342 (M+1)+; 1H NMR (DMSO-d6, 400 MHz): δ 1.22 (d, 6H); 2.92 (m, 1H); 4.04 (s, 2H); 7.17 (s, 1H); 7.33 (d, 2H); 7.66 (d, 2H); 12.98 (s); 13.2 (s).