Hydrochloric Acid → {[4-(4-Isopropyl-phenyl)-thiazol-2-yl]-thiophen-2-ylmethyl-sulfamoyl}-acetic acid

反応式

C([O:5][C:6](=[O:32])[CH2:7][S:8](=[O:31])(=[O:30])[N:9]([C:16]1[S:17][CH:18]=[C:19]([C:21]2[CH:26]=[CH:25][C:24]([CH:27]([CH3:29])[CH3:28])=[CH:23][CH:22]=2)[N:20]=1)[CH2:10][C:11]1[S:12][CH:13]=[CH:14][CH:15]=1)(C)(C)C.Cl>>[CH:27]([C:24]1[CH:23]=[CH:22][C:21]([C:19]2[N:20]=[C:16]([N:9]([CH2:10][C:11]3[S:12][CH:13]=[CH:14][CH:15]=3)[S:8]([CH2:7][C:6]([OH:32])=[O:5])(=[O:30])=[O:31])[S:17][CH:18]=2)=[CH:26][CH:25]=1)([CH3:29])[CH3:28]

参加物

反応物 2

HCID 313Hydrochloric Acid

HCID 68647641{[4-(4-Isopropyl-phenyl)-thiazol-2-yl]-thiophen-2-ylmethyl-sulfamoyl}-acetic acid tert-butyl ester

生成物 1

HCID 59520347{[4-(4-Isopropyl-phenyl)-thiazol-2-yl]-thiophen-2-ylmethyl-sulfamoyl}-acetic acid

実験手順

The above ester was treated with 4M HCl as outlined in general procedure G1 to provide {[4-(4-Isopropyl-phenyl)-thiazol-2-yl]-thiophen-2-ylmethyl-sulfamoyl}-acetic acid. LCMS m/z: 438 (M+1)+.

出典と根拠

ORDレコード: ord-8e8ebdbd7a044317bc611066d2c81548
出典データセット: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07820704B2

反応ノート

読み込み中…